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安巴拉·拉赫馬特/ Ambara Rachmat Pradipta

  • Education:
      1999/09 - 2003/08    Padjadjaran University, Faculty of Mathematics and Natural
        Sciences, Department of Chemistry (B.Sc.)
      2005/10 - 2006/03    Osaka University, School of Science,
        Department of Chemistry (Research Student)
      2006/04 - 2008/03    Osaka University, Graduate School of Science,
        Department of Chemistry (M.Sc.)
      2006/04 - 2008/03    Osaka University, Graduate School of Science,
        Department of Chemistry (Ph.D.)

    Work experience:
      2003/09 - 2005/08    Industrial Experience
      2011/04 - 2012/03    Osaka University, Postdoctoral Researcher (GCOE Fellow)
      2012/04 - 2017/03    RIKEN, Postdoctoral Researcher
      2015/04 - 2020/03    Tokyo Medical and Dental University, Visiting Lecturer
        (additional position)
      2017/04 - 2020/03    RIKEN, Special Postdoctoral Researcher
      2020/04 - Present    Tokyo Institute of Technology, Assistant Professor
      2020/07 - Present    RIKEN, Visiting Scientist (additional position)
  • Biofunctional chemistry 

     

  • 1. A. Kubo, T. Tanei, A. R. Pradipta, K. Morimoto, M. Fujii, Y. Sota, T. Miyake, N. Kagara, M. Shimoda, Y. Naoi, Y. Motoyama, E. Morii, K. Tanaka, K. Shimazu; Comparison of “click-to-sense” assay with frozen section analysis using simulated surgical margins in breast cancer patients; Eur. J. Surg. Oncol. 2022, DOI: doi.org/10.1016/j.ejso.2022.04.003.
    2. A. R. Pradipta,* H. Michiba, A. Kubo, M. Fujii, T. Tanei, K. Morimoto, K. Shimazu, K. Tanaka; The second-generation click-to-sense probe for intraoperative diagnosis of breast cancer tissues based on acrolein targeting; Bull. Chem. Soc. Jpn. 2022, 95, 421-426. [*Corresponding author]
    3. R. Kunitomi, A. R. Pradipta, H. Kawabe, N. Lobsiger, K. Tanaka, T. Zako; Inhibition of amyloid formation of amyloid β(1-42), amylin and insulin by 1,5-diazacyclooctanes, as spermine-acrolein conjugate;Bioorg. Med. Chem. 2021, 46, 116391.
    4. A. R. Pradipta,* P. Ahmadi, K. Terashima, K. Muguruma, M. Fujii, T. Ichino, S. Maeda, K. Tanaka; Targeted 1,3-dipolar cycloaddition with acrolein for cancer prodrug activation; Chem. Sci. 2021, 12, 5438-5449. [*Corresponding author] [2021 Chemical Science HOT Article 
    Collection] [Journal Cover]
    5. I. Smirnov, R. Sibgatullina, S. Urano, T. Tahara, P. Ahmadi, Y. Watanabe, A. R. Pradipta, A. Kurbangalieva, K. Tanaka; A strategy for tumor targeting by higher-order glycan pattern recognition: Synthesis and in vitro and in vivo properties of glycoalbumins conjugated with four different N-glycan molecules; Small 2020, 16, 2004831. [Journal Cover]
    6. O. A. Lodochnikova, D. R. Chulakova, D. P. Gerasimova, I. A. Litvinov, A. R. Pradipta, K. Tanaka, A. R. Kurbangalieva; Stereochemical features of the crystallization of eight-membered 1,5-diazaheterocycles with chiral aminoindanol fragments at nitrogen atoms; J. Struct. Chem. 2020, 61, 119-125.
    7. D. R. Chulakova, A. R. Pradipta,* O. A. Lodochnikova, D. R. Kuznetsov, K. S. Bulygina, I. S. Smirnov, K. S. Usachev, L. Z. Latypova, A. R. Kurbangalieva, K. Tanaka; Facile access to optically active 2,6-dialkyl-1,5-diazacyclooctanes; Chem. Asian J. 2019, 14, 4048-4054. [*Corresponding author] [Invited in ‘18th Asian Chemical Congress’ Special Issue]
    8. A. R. Pradipta, M. Fujii, T. Tanei, K. Morimoto, K. Shimazu, S. Noguchi, K. Tanaka; Tetramethylrhodamine is an essential scaffold of azide probe in detecting cellular acrolein; Bioorg. Med. Chem. 2019, 27, 2228-2234. 
    9. T. Tanei,# A. R. Pradipta,# K. Morimoto, M. Fujii, M. Arata, A. Ito, M. Yoshida, E. Saigitbatalova, A.  Kurbangalieva, J.-I. Ikeda, E. Morii, S. Noguchi, K. Tanaka; Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology; Adv. Sci. 2019, 6, 1801479. [#Equal contribution] [Journal Cover]
    10. Y. Qi, X. Zhao, J. Chen, A. R. Pradipta, J. Wei, H. Ruan, L. Zhou, R. P. Hsung, K. Tanaka; In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6; Biosci. Biotechnol. Biochem. 2019, 83, 1011-1026.
    11. Y. Nakamoto, A. R. Pradipta, H. Mukai, M. Zouda, Y. Watanabe, A. Kurbangalieva, P. Ahmadi, Y. Manabe, K. Fukase, K. Tanaka; Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium-68 positron emission tomography;
    ChemBioChem 2018, 19, 2055-2060. [Invited in ‘ChemBioTalents’ Themed Issue]
    12. A. Tsutsui, A. R. Pradipta, S. Kitazume, N. Taniguchi, K. Tanaka; Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism;
    Org. Biomol. Chem. 2017, 15, 6720-6724.
    13. Y. Qi, A. R. Pradipta, M. Li, X. Zhao, L. Lu, X. Fu, J. Wei, R. P. Hsung, K. Tanaka, L. Zhou; Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6; J. Exp. Clin. Cancer Res. 2017, 36, 35.
    14. K. Tsubokura, K. K. H. Vong, A. R. Pradipta, A. Ogura, S. Urano, T. Tahara, S. Nozaki, H. Onoe, Y.  Nakao, R. Sibgatullina, A. Kurbangalieva, Y. Watanabe, K. Tanaka; In vivo gold complex catalysis within live mice; Angew. Chem. Int. Ed. 2017, 56, 3579-3584. [Hot Paper]
    15. A. R. Kurbangalieva, L. T. Hoang, O. A. Lodochnikova, M. Y. Kuzmicheva, A. R. Pradipta, K. Tanaka, G. A. Chmutova; First example of synthesis of S,O-macroheterocycle on the basis of 2(5H)-furanone and 2,2’-oxydiethanethiol; Russ. Chem. Bull. Int. Ed. 2016, 5, 1278-1284.
    16. A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi,  K. Tanaka; Uncatalyzed click reaction between phenyl azides and acrolein: 4-Formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively 
    stressed cells; ACS Sens. 2016, 1, 623-632.
    17. A. R. Pradipta, K. Tanaka; Unexplored reactivity of N-alkyl unsaturated imines: A simple procedure for producing optically active 1,3-diamines via a stereocontrolled formal [4+2] and [4+2+2] iminocycloaddition; Bull. Chem. Soc. Jpn. 2016, 89, 337-345. [Selected Paper]
    18. Q. Wang, Y. Matsuo, A. R. Pradipta, N. Inohara, K. Fukase, Y. Fujimoto; Modulation of nucleotide-binding oligomerization protein (NOD)1 and NOD2 signaling by  diaminopimelic acid (DAP)-containing Mycobacterium peptidoglycan (PGN) fragments: Synthesis and biological evaluation;
    Org. Biomol. Chem. 2016, 14, 1013-1023. [Hot Article] 19. A. Tsutsui, A. R. Pradipta, E. Saigitbatalova, A. Kurbangalieva, K. Tanaka; Exclusive formation of imino [4+4] cycloaddition products with biologically relevant amines:  Plausible candidates of acrolein biomarkers and biofunctional modulators; Med. Chem. Commun. 2015, 6, 431-436. [Journal Cover]
    20. A. R. Pradipta, A. Tsutsui, A. Ogura, S. Hanashima, Y. Yamaguchi, A. Kurbangalieva, K. Tanaka; Microfluidic mixing of polyamine with acrolein enables the detection of the [4+4]  polymerization of intermediary unsaturated imines: The properties of a cytotoxic 1,5- diazacyclooctane hydrogel; Synlett 2014, 25, 2442-2446.
    21. K. Tanaka, R. Matsumoto, A. R. Pradipta, Y. Kitagawa, M. Okumura, Y. Manabe, K. Fukase; Facile preparation of 1,5-diazacyclooctanes from unsaturated imines: Effects of the hydroxyl  groups on [4 + 4] dimerization; Synlett 2014, 25, 1026-1030.
    22. K. Tanaka, M. Kitadani, A. Tsutsui, A. R. Pradipta, R. Imamaki, S. Kitazume, N. Taniguchi, K. Fukase; A cascading reaction sequence involving ligand-directed azaelectrocyclization and  autooxidation-induced fluorescence recovery enables visualization of target proteins on the 
    surfaces of live cells; Org. Biomol. Chem. 2014, 12, 1412-1418.
    23. K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, K. Fukase;
    Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation; Org. Biomol. Chem. 2013, 11, 7326-7333.
    24. K. Tanaka, E. R. O. Siwu, S. Hirosaki, T. Iwata, R. Matsumoto, Y. Kitagawa, A. R. Pradipta, M. Okumura, K. Fukase; Efficient synthesis of 2,6,9-triazabicyclo[3.3.1]nonanes through amine mediated formal [4 + 4] reaction of unsaturated imines; Tetrahedron Lett. 2012, 53, 5899-5902.
    25. A. R. Pradipta, Y. Fujimoto, M. Hasegawa, N. Inohara, K. Fukase; Characterization of natural human NOD1 ligands from bacterial culture supernatant for elucidation of immune system activation in the environment; J. Biol. Chem. 2010, 285, 23607-23613.